Protein-coding gene in the species Homo sapiens
Tyrosine -protein kinase TXKenzyme that in humans is encoded by the TXK gene .[ 5] [ 6] [ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000074966 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054892 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Haire RN, Ohta Y, Lewis JE, Fu SM, Kroisel P, Litman GW (Nov 1994). "TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12". Hum Mol Genet . 3 (6): 897– 901. doi :10.1093/hmg/3.6.897 . PMID 7951233 . ^ Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12" . Genomics . 22 (2): 431– 6. doi :10.1006/geno.1994.1405 PMID 7528718 . ^ "Entrez Gene: TXK TXK tyrosine kinase" .
Further reading
Suzuki N, Nara K, Suzuki T (2006). "Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease" . Clinical Medicine & Research . 4 (2): 147– 51. doi :10.3121/cmr.4.2.147 . PMC 1483892 PMID 16809408 . Ohta Y, Haire RN, Amemiya CT, et al. (1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene". Oncogene . 12 (4): 937– 42. PMID 8632917 . Wardenburg JB, Fu C, Jackman JK, et al. (1996). "Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function" . J. Biol. Chem . 271 (33): 19641– 4. doi :10.1074/jbc.271.33.19641 PMID 8702662 . Raab M, da Silva AJ, Findell PR, Rudd CE (1997). "Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2" . Immunity . 6 (2): 155– 64. doi :10.1016/S1074-7613(00)80422-7 PMID 9047237 . Schneider H, Schwartzberg PL, Rudd CE (1998). "Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4". Biochem. Biophys. Res. Commun . 252 (1): 14– 9. doi :10.1006/bbrc.1998.9559 . PMID 9813138 . Rajagopal K, Sommers CL, Decker DC, et al. (2000). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation" . J. Exp. Med . 190 (11): 1657– 68. doi :10.1084/jem.190.11.1657 . PMC 2195727 PMID 10587356 . Schneider H, Guerette B, Guntermann C, Rudd CE (2000). "Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells" . J. Biol. Chem . 275 (6): 3835– 40. doi :10.1074/jbc.275.6.3835 PMID 10660534 . Chamorro M, Czar MJ, Debnath J, et al. (2004). "Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk" . BMC Immunol . 2 : 3. doi :10.1186/1471-2172-2-3 PMC 31577 PMID 11353545 . Takeba Y, Nagafuchi H, Takeno M, et al. (2002). "Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription" . J. Immunol . 168 (5): 2365– 70. doi :10.4049/jimmunol.168.5.2365 PMID 11859127 . Kashiwakura J, Suzuki N, Takeno M, et al. (2002). "Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site" . Biol. Pharm. Bull . 25 (6): 718– 21. doi :10.1248/bpb.25.718 PMID 12081135 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Rafalska I, Zhang Z, Benderska N, et al. (2005). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation" . Hum. Mol. Genet . 13 (15): 1535– 49. doi :10.1093/hmg/ddh167 PMID 15175272 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55– 65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 .
Activity Regulation Classification Kinetics Types
