St. Columba's School may refer to:

• St. Columba's Primary School, Wilston, Queensland

• St. Columba's School, Delhi

• SMK St. Columba, Miri
• SK St Columba, Miri

• St Columba's Catholic Boys' School, London, England
• St Columba's School, Kilmacolm, Renfrewshire, Scotland

• St. Columba's School (Schenectady, New York), listed on the National Register of Historic Places

• St Columba's College (disambiguation)