Spiro(s) may refer to:

• Spiro, Oklahoma, a town in the U.S.
  • Spiro Mounds, an archaeological site
• Spiro (band), a British music group
• Spiro (name), including a list of people with the name
• Špiro, South Slavic masculine given name
• ARA Spiro, two ships of the Argentine Navy
• SS Spiro, an oil tanker
• Euler spiral, or spiro, a curve
• Spiro compound, a type of chemical structure
• Spironolactone, a medicine, often used in feminizing hormone therapy

• All pages with titles containing Spiro
• All pages with titles beginning with Spiro
• Spiro compound, a class of organic compound featuring two rings joined at one atom
• Spirou (comics), a Belgian comic strip character
• Spyro
• Spira (disambiguation)