Sayf al-Din Muhammad (Persian: سیف الدین محمد) was the king of the Ghurid dynasty from 1161 to 1163. He was the son and successor of Ala al-Din Husayn.

After the accession of Sayf, he began persecution of the Ismailis who were favored during the reign of his father. Sayf also freed the two sons of Baha al-Din Sam I, Ghiyath al-Din Muhammad and Mu'izz al-Din Muhammad.^[1] With the aid of Ghiyath al-Din Muhammad, Sayf later waged war against the Oghuz Turks. Sayf was betrayed and murdered during a battle in 1163 near Merv by a brother of the Ghurid general Warmesh ibn Shith, whom Sayf had executed. Sayf was then succeeded by Ghiyath.

• C. Edmund, Bosworth (2001). "GHURIDS". Encyclopaedia Iranica, Online Edition. Retrieved 11 January 2014.
• Bosworth, C. E. (1968). "The Political and Dynastic History of the Iranian World (A.D. 1000–1217)". In Frye, R. N. (ed.). The Cambridge History of Iran, Volume 5: The Saljuq and Mongol periods. Cambridge: Cambridge University Press. pp. 1–202. ISBN 0-521-06936-X.
• C. E., Bosworth (2012). "G̲h̲ūrids". Encyclopaedia of Islam, Second Edition. Leiden and New York: BRILL. ISBN 9789004161214.