SFE may refer to:

• Sales force effectiveness
• San Fernando Airport (Philippines) IATA code
• Scottish Financial Enterprise, trade body for the financial services sector in Scotland
• Scouts for Equality, advocates for scouts and leaders in the Boy Scouts of America
• Secure function evaluation, in cryptography
• Sigma Phi Epsilon
• Shannon-Fano-Elias coding, a lossless data compression algorithm
• Society of Fuse Engineers, designers of certain automotive fuses
• Solar flare effect
• SparkFun Electronics
• Spec Files Extra, a way to build common packages for OpenSolaris or OpenIndiana
• Stacking-fault energy
• Student Finance England, see Student Loans Company
• Supercritical fluid extraction
• Supplier-furnished equipment
• Surface free energy, often referred to as Surface energy
• Sydney Futures Exchange, now merged with the Australian Stock Exchange to become the Australian Securities Exchange
• The Encyclopedia of Science Fiction