Protein-coding gene in the species Homo sapiens
Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme subunit that in humans is encoded by the PIK3C3 gene .[ 5] [ 6] class III phosphoinositide 3-kinase .
References
^ a b c GRCh38: Ensembl release 89: ENSG00000078142 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033628 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD (Sep 1995). "A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system" . EMBO J . 14 (14): 3339– 48. doi :10.1002/j.1460-2075.1995.tb07340.x . PMC 394401 PMID 7628435 . ^ "Entrez Gene: PIK3C3 phosphoinositide-3-kinase, class 3" .
Further reading
Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways" . J. Leukoc. Biol . 74 (5): 676– 82. doi :10.1189/jlb.0503206 PMID 12960231 . S2CID 11362623 . Vogel LB, Fujita DJ (1994). "The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes" . Mol. Cell. Biol . 13 (12): 7408– 17. doi :10.1128/mcb.13.12.7408 . PMC 364812 PMID 7504174 . Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells" . J. Biol. Chem . 271 (38): 22961– 4. doi :10.1074/jbc.271.38.22961 PMID 8798481 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791– 806. doi :10.1101/gr.6.9.791 PMID 8889548 . Panaretou C, Domin J, Cockcroft S, Waterfield MD (1997). "Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex" . J. Biol. Chem . 272 (4): 2477– 85. doi :10.1074/jbc.272.4.2477 PMID 8999962 . Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". Eur. J. Immunol . 27 (9): 2457– 65. doi :10.1002/eji.1830270946 . PMID 9341793 . S2CID 33397908 . Borgatti P, Zauli G, Colamussi ML, et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol . 27 (11): 2805– 11. doi :10.1002/eji.1830271110 . PMID 9394803 . S2CID 6303471 . Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochem. Biophys. Res. Commun . 242 (2): 332– 7. doi :10.1006/bbrc.1997.7877 . PMID 9446795 . Milani D, Mazzoni M, Zauli G, et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells" . AIDS . 12 (11): 1275– 84. doi :10.1097/00002030-199811000-00008 PMID 9708406 . S2CID 25758704 . Jauliac S, Mazerolles F, Jabado N, et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity" . Eur. J. Immunol . 28 (10): 3183– 91. doi :10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A PMID 9808187 . Park IW, Wang JF, Groopman JE (2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes" . Blood . 97 (2): 352– 8. doi :10.1182/blood.V97.2.352 PMID 11154208 . Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway" . FASEB J . 15 (2): 483– 91. doi :10.1096/fj.00-0354com PMID 11156964 . S2CID 26315564 . Deregibus MC, Cantaluppi V, Doublier S, et al. (2002). "HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells" . J. Biol. Chem . 277 (28): 25195– 202. doi :10.1074/jbc.M200921200 PMID 11994280 . Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism" . J. Immunol . 169 (1): 254– 60. doi :10.4049/jimmunol.169.1.254 PMID 12077252 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . François F, Klotman ME (2003). "Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages" . J. Virol . 77 (4): 2539– 49. doi :10.1128/JVI.77.4.2539-2549.2003 . PMC 141101 PMID 12551992 . Vergne I, Chua J, Deretic V (2003). "Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade" . J. Exp. Med . 198 (4): 653– 9. doi :10.1084/jem.20030527 . PMC 2194170 PMID 12925680 . Khan NA, Di Cello F, Nath A, Kim KS (2004). "Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells". J. Neurovirol . 9 (6): 584– 93. doi :10.1080/jnv.9.6.584.593 . PMID 14602571 .
