Mark McKenzie or Mark MacKenzie may refer to:

• Mark Mackenzie (1888–1914), Scottish cricketer
• Mark McKenzie (composer) (born 1957), American film score composer
• Mark McKenzie (rugby union) (born 1971), Scottish rugby union player
• Mark McKenzie (soccer, born 1999), American soccer player
• Mark McKenzie (footballer, born 2000), Scottish football player
• Mark MacKenzie, American politician
• Mark McKenzie (Australian footballer), Australian rules football player for Woodville-West Torrens Football Club
• Marc MacKenzie, a character in Family Affairs
• Marc McKenzie (born 1985), Scottish football player