MCR may refer to:

• Modena City Ramblers, an Italian folk rock band
• My Chemical Romance, an American rock band
• "MCR Calling," a track from the album Manchester Calling.

• Maryport and Carlisle Railway, M&CR, a pre-grouping British railway company
• Midland Counties Railway, an early British railway company
• Muslim Community Radio, a radio station based in London, UK
• Middle common room, a postgraduate student organization
• Marine Commando Regiment, Canada
• Romandy Citizens' Movement (French: Mouvement Citoyens Romand), Swiss political party
• MCR Property Group, a real estate group founded by Aneel Mussarat
• MCR Hotels

• Methyl coenzyme M reductase, an enzyme that occurs in methanogenic archea
• Micro Carbon Residue, a petroleum industry test
• Mineralocorticoid receptor, a protein
• Multi-component reaction, chemical reaction
• Mutual Climatic Range, for determining past climate at an archaeological site

• Move to Coprocessor from Register, an ARM architecture CPU instruction
• Critical Mach number (Mcr), in aeronautics
• Maximum continuous rating, of a generating station
• Multi-component refrigerant
• Monitor Console Routine, of RSX-11 operating system

• Medical care ratio, a healthcare metric
• Master control room, a room for routing all incoming and outgoing signals
• Master of Clinical Research, an academic degree
• Marri Channa Reddy (1919–1996), Indian politician
• MCR HRD Institute, a training institute named for Marri Channa Reddy
• Manchester City Region

• All pages with titles beginning with MCR
• All pages with titles containing MCR