A life sentence is a term of imprisonment for a crime that is intended to last for life.

Life Sentence may also refer to:

• Life Sentence (TV series), an American TV series
• Life Sentence (EP), a 2003 EP by Epicure
• "Life Sentence" (Arrow), a 2018 television episode
• "Life Sentence" (Waking the Dead), a 2002 television episode

• Life Sentence to Love, an album by Legal Weapon