LDH is an acronym which may refer to:

• Lai Đại Hàn
• IATA code for Lord Howe Island Airport, New South Wales, Australia
• Lactate dehydrogenase, an enzyme in a wide range of plants, animals and other organisms; is measured as part of the complete blood test
• Large-diameter hose, a type of fire hose
• Layered double hydroxides, a class of layered materials composed of positively charged atomic layers and charge balancing anions located in the interlayer region
• Letters Digits Hyphen rule in RFCs defining DNS: RFC 1034, RFC 1035, RFC 1123, RFC 3696, RFC 5890
• Human Rights League (France) (French: Ligue des droits de l'homme)
• LDH (company), Japanese entertainment company