I-180 may refer to:

• Interstate 180, one of several roads:
  • Interstate 180 (California), a temporary designation used in 1978 for the Richmond–San Rafael Bridge in the San Francisco Bay Area in California that is now part of Interstate 580
  • Interstate 180 (Illinois), a short spur in rural Putnam and Bureau counties in northern Illinois
  • Interstate 180 (Nebraska), a spur in Lincoln, Nebraska
  • Interstate 180 (Pennsylvania), a spur to Williamsport, Pennsylvania
  • Interstate 180 (Wyoming), a short, non-freeway spur in Cheyenne, Wyoming
  • Interstate 176 to Reading, Pennsylvania, designated as Interstate 180 when I-76 was I-80S
• Polikarpov I-180
• Japanese submarine I-180