Helen Katherine Myers Sharsmith (August 26, 1905 – November 10, 1982) was an American biologist.

Helen Sharsmith was born in 1905 in Oakland, California. She received an AB and MA from the University of California, Berkeley, in 1927 and 1928, and then worked as a high school and junior college teacher. The Jepson Herbarium recognized her contributions at the University of California, Berkeley, publishing a document titled “First Women Botanists at Berkeley,” which includes biographical material on Helen Katherine Meyers Sharsmith (1905–1982).^[1]

She met her future husband, Carl Sharsmith, while taking a class at the Yosemite Outdoor Field School in Yosemite National Park. She and her husband married and earned doctorates from the University of California, Berkeley, in 1940.

Sharsmith worked as a research assistant at the University of California and as a biology teacher while pursuing her degree. Later, she worked as a biology assistant at the Carnegie Institution of Washington and a senior botanist at Berkeley, where she retired in 1969.

Sharsmith’s dissertation, Flora of the Mount Hamilton Range of California (1945), was later published as a book. This was the result of extensive field research in the area. She also wrote Spring Wildflowers of the San Francisco Bay Region (1965).

The Sharsmiths had two children, a son and a daughter. They were later divorced.

• Sharsmith's stickseed (Hackelia sharsmithii) — named for her husband by I.M. Johnston, but discovered by Sharsmith and her husband Carl Sharsmith at Mirror Lake after climbing Mount Whitney
• Sharsmith's Onion (Allium sharsmithiae) (Ownbey & Aase ex Traub) McNeal — Aliso or Allium fimbriatum S. Watson var. sharsmithiae Ownbey & Aase ex Traub.). Endemic to Mount Hamilton area of the Diablo Range in the southeastern San Francisco Bay Area.
• Sharsmith's harebell (Campanula sharsmithiae), or Mt. Hamilton Bellflower (N. Morin) — endemic to Mount Hamilton area of the Diablo Range in the southeastern San Francisco Bay Area.
• Sharsmith's draba (Draba sharsmithii), or Mount Whitney draba (Rollins and R.A. Price) — endemic to southern Sierra Crest in Mount Whitney area.

• O'Neill, Elizabeth Stone, Mountain Sage: The Life of Carl Sharsmith Yosemite Ranger/Naturalist 2d ed. (1996) ISBN 0-939666-47-2.