Protein-coding gene in humans
F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene .[ 5] [ 6] [ 7]
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif , the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation -dependent ubiquitination . The F-box proteins are divided into three classes: Fbws containing WD-40 domains , Fbls containing leucine -rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000174989 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032867 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins" . Curr Biol . 9 (20): 1177– 9. Bibcode :1999CBio....9.1177C . doi :10.1016/S0960-9822(00)80020-2 PMID 10531035 . S2CID 7467493 . ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins" . Curr Biol . 9 (20): 1180– 2. Bibcode :1999CBio....9.1180W . doi :10.1016/S0960-9822(00)80021-4 PMID 10531037 . S2CID 14341845 . ^ a b "Entrez Gene: FBXW8 F-box and WD repeat domain containing 8" .
Further reading
Tsutsumi T, Kuwabara H, Arai T, et al. (2008). "Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice" . Mol. Cell. Biol . 28 (2): 743– 51. doi :10.1128/MCB.01665-07 . PMC 2223430 PMID 17998335 . Koch HB, Zhang R, Verdoodt B, et al. (2007). "Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach" . Cell Cycle . 6 (2): 205– 17. doi :10.4161/cc.6.2.3742 PMID 17314511 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Watanabe N, Arai H, Nishihara Y, et al. (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP" . Proc. Natl. Acad. Sci. U.S.A . 101 (13): 4419– 24. Bibcode :2004PNAS..101.4419W . doi :10.1073/pnas.0307700101 PMC 384762 PMID 15070733 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Dias DC, Dolios G, Wang R, Pan ZQ (2003). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16601– 6. doi :10.1073/pnas.252646399 PMC 139190 PMID 12481031 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 .
