Druce is a surname. Notable people with the surname include:

• Duncan Druce (1939–2015), British composer and musicologist
• Eliot Druce (1876–1934), English cricketer
• Frank Druce (1875–1954), English cricketer
• George Claridge Druce (1850–1932), British botanist
• Helen Margaret Druce (1921–2010), New Zealand teacher, tramper, botanist and botanical collector
• Herbert Druce (1846–1913), British entomologist
• Hamilton Herbert Druce (1869–1922), British entomologist, son of the above
• John Druce (born 1966), Canadian ice hockey player
• Joseph Druce (born 1965), American prisoner who murdered John Geoghan
• Olga Druce, American radio and television producer, public speaker, and actress
• Thomas W. Druce (born 1961), former member of the Pennsylvania House of Representatives, US