Calais is a city in France. The name can also refer to:

• Calais, Maine, United States, a city
• Calais, Vermont, United States, a town
• Arrondissement of Calais, France
• Calais (Parliament of England constituency), represented before the French reconquest in the 16th century
• Calais, Alberta, Canada, an unincorporated community
• Calais, Limpopo, South Africa, a village
• Mount Calais, Alexander Island, Antarctica
• A crater on Saturn's moon Phoebe (moon)

• Cadillac Calais
• Oldsmobile Cutlass Calais
• Holden Calais

• Calaïs /ˈtæliəs/, one of the Boreads in Greek mythology
• Saint Calais, French hermit-saint, namesake of commune of Saint-Calais
• Calais Campbell (born 1986), American National Football League player

• Calais (beetle), a genus of click beetles
• Calais (Reuters product), an internet toolkit
• Calais RUFC, a former French football club
• Calais Railroad, Maine