Protein-coding gene in humans
Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene .[ 5] [ 6] [ 7]
Function CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.[ 7]
Interactions CDC42EP2 has been shown to interact with CDC42 [ 5] [ 6] RHOQ .[ 5]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000149798 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045664 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b c Joberty G, Perlungher RR, Macara IG (Oct 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins" . Molecular and Cellular Biology . 19 (10): 6585– 97. doi :10.1128/MCB.19.10.6585 . PMC 84628 PMID 10490598 . ^ a b Hirsch DS, Pirone DM, Burbelo PD (Jan 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes" . The Journal of Biological Chemistry . 276 (2): 875– 83. doi :10.1074/jbc.M007039200 PMID 11035016 . ^ a b "Entrez Gene: CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2" .
External links
Further reading
Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, Marx SJ, Burns L, Chandrasekharappa SC (Jul 1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus" . Genome Research . 7 (7): 725– 35. doi :10.1101/gr.7.7.725 . PMC 310681 PMID 9253601 . Burbelo PD, Snow DM, Bahou W, Spiegel S (Aug 1999). "MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts" . Proceedings of the National Academy of Sciences of the United States of America . 96 (16): 9083– 8. Bibcode :1999PNAS...96.9083B . doi :10.1073/pnas.96.16.9083 PMC 17736 PMID 10430899 . Joberty G, Perlungher RR, Sheffield PJ, Kinoshita M, Noda M, Haystead T, Macara IG (Oct 2001). "Borg proteins control septin organization and are negatively regulated by Cdc42". Nature Cell Biology . 3 (10): 861– 6. doi :10.1038/ncb1001-861 . PMID 11584266 . S2CID 58805 . Xue Y, Bi F, Zhang X, Zhang S, Pan Y, Liu N, Shi Y, Yao X, Zheng Y, Fan D (Jun 2006). "Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation" . International Journal of Cancer . 118 (12): 2965– 72. doi :10.1002/ijc.21763 PMID 16395716 . S2CID 39137777 .
