Protein-coding gene in the species Homo sapiens
ATP6AP2 Identifiers Aliases ATP6AP2 External IDs OMIM : 300556 ; MGI : 1917745 ; HomoloGene : 38097 ; GeneCards : ATP6AP2 ; OMA :ATP6AP2 - orthologs Wikidata
The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2 , or the prorenin receptor , is a protein that in humans is encoded by the ATP6AP2 gene .[ 5] [ 6] [ 7]
Function The renin receptor binds renin and prorenin . Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I .[ 8]
This protein is associated with proton-translocating ATPases which have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000182220 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031007 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules" . J Biol Chem . 273 (18): 10939– 47. doi :10.1074/jbc.273.18.10939 PMID 9556572 . ^ Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis . 7 : 234– 9. PMID 11590366 . ^ a b "Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2" .^ Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD (June 2002). "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin" . J. Clin. Invest . 109 (11): 1417– 27. doi :10.1172/JCI14276 . PMC 150992 PMID 12045255 .
Further reading
Kaneshiro Y, Ichihara A, Sakoda M, et al. (2007). "Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats" (PDF) . J. Am. Soc. Nephrol . 18 (6): 1789– 95. doi :10.1681/ASN.2006091062 PMID 17494887 . Schefe JH, Menk M, Reinemund J, et al. (2007). "A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein" . Circ. Res . 99 (12): 1355– 66. CiteSeerX 10.1.1.486.8053 doi :10.1161/01.RES.0000251700.00994.0d PMID 17082479 . Kaneshiro Y, Ichihara A, Takemitsu T, et al. (2006). "Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats" . Kidney Int . 70 (4): 641– 6. doi :10.1038/sj.ki.5001627 PMID 16807542 . Burcklé CA, Jan Danser AH, Müller DN, et al. (2006). "Elevated blood pressure and heart rate in human renin receptor transgenic rats" . Hypertension . 47 (3): 552– 6. doi :10.1161/01.HYP.0000199912.47657.04 PMID 16401765 . Huang Y, Wongamorntham S, Kasting J, et al. (2006). "Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms" . Kidney Int . 69 (1): 105– 13. doi :10.1038/sj.ki.5000011 PMID 16374430 . Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries" . DNA Res . 12 (2): 117– 26. doi :10.1093/dnares/12.2.117 PMID 16303743 . Ramser J, Abidi FE, Burckle CA, et al. (2005). "A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor". Hum. Mol. Genet . 14 (8): 1019– 27. doi :10.1093/hmg/ddi094 . PMID 15746149 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Hedera P, Alvarado D, Beydoun A, Fink JK (2002). "Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4". Ann. Neurol . 51 (1): 45– 50. doi :10.1002/ana.10051 . hdl :2027.42/34887 PMID 11782983 . S2CID 18107509 . Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning" . Proc. Natl. Acad. Sci. U.S.A . 97 (17): 9543– 8. Bibcode :2000PNAS...97.9543H . doi :10.1073/pnas.160270997 PMC 16901 PMID 10931946 .
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