Apoc may refer to:

• African Programme for Onchocerciasis Control, a World Bank and World Health Organization NGO
• Apolipoprotein C, a family of four proteins that resides on lipoproteins.
• Anglo-Persian Oil Company, later BP
• Anarchist People of Color
• APOC (wrestler) is the ring name of a professional wrestler.
• Apoc, a character in the Matrix series
• Assistant production office coordinator, a film and television administrative job