2010 Presbyterian Blue Hose football
Conference	Big South Conference
Record	0–9, 2 wins vacated (0–5 Big South, 1 win vacated)
Head coach	Harold Nichols (2nd season)
Home stadium	Bailey Memorial Stadium
Seasons ← 2009 2011 →

The 2010 Presbyterian Blue Hose football team represented Presbyterian College as a member of the Big South Conference during the 2010 NCAA Division I FCS football season Led by second-year head coach Harold Nichols, the Blue Hose finished the season with an overall record of 2–9 and a mark of 1–5 in conference play, tying for sixth place in the Big South. Presbyterian was later vacated both wins from the season because the team has used an ineligible player. The Blue Hose played home games at Bailey Memorial Stadium in Clinton, South Carolina.

Date	Time	Opponent	Site	TV	Result	Attendance
September 2	6:30 p.m.	at Wake Forest*	BB&T Field Winston-Salem, NC	ESPN3	L 13–53	28,205
September 11	3:30 p.m.	at Clemson*	Memorial Stadium Clemson, SC	ESPN3	L 21–58	70,500
September 18	7:40 p.m.	at The Citadel*	Johnson Hagood Stadium Charleston, SC		L 14–26	12,792
September 25	Noon	North Greenville*	Bailey Memorial Stadium Clinton, SC	BSN	L 17–34	3,093
October 2	1:30 p.m.	at VMI	Alumni Memorial Field Lexington, VA	BSN	L 13–24	5,719
October 16	2:00 p.m.	Coastal Carolina	Bailey Memorial Stadium Clinton, SC	BSN	L 7–35	4,753
October 23	1:30 p.m.	at Gardner–Webb	Spangler Stadium Boiling Springs, NC	BSN	W 26–24 (vacated)	6,125
October 30	1:30 p.m.	Liberty	Bailey Memorial Stadium Clinton, SC	BSN	L 24–34	3,140
November 6	1:00 p.m.	Stony Brook	Bailey Memorial Stadium Clinton, SC	SportSouth	L 7–37	1,667
November 13	1:30 p.m.	at Charleston Southern	Buccaneer Field Charleston, SC		L 39–42	3,429
November 20	1:00 p.m.	Davidson*	Bailey Memorial Stadium Clinton, SC	BSN	W 42–6 (vacated)
*Non-conference game Homecoming All times are in Eastern time

^[1][2][3]