The 2000 Canisius Golden Griffins football team represented Canisius College as a member of the Metro Atlantic Athletic Conference (MAAC) during the 2000 NCAA Division I-AA football season. Led by first-year head coach Ed Argast, the Golden Griffins compiled an overall record of 0–10 with a mark of 0–7 in conference play, placing last out of nine teams in the MAAC. The Canisius offense scored 100 points while the defense allowed 373 points.[1]