VNN1

VNN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CYF, 4CYG, 4CYY
Identifiers
Aliases	VNN1, HDLCQ8, Tiff66, vanin 1
External IDs	MGI: 108395; HomoloGene: 32130; GeneCards: VNN1; OMA:VNN1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	132,714,055 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	23,781,241 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	8876
	22361
	ENSG00000112299
	ENSMUSG00000037440
	O95497
	Q9Z0K8
	NM_004666
	NM_011704
	NP_004657
	NP_035834
	Wikidata
View/Edit Human	View/Edit Mouse

Pantetheinase is an enzyme that in humans is encoded by the VNN1 gene.^[5]^[6]

This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112299 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037440 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P (Dec 1998). "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6". Genomics. 53 (2): 203–13. doi:10.1006/geno.1998.5481. PMID 9790769.
^ ^a ^b "Entrez Gene: VNN1 vanin 1".

Aurrand-Lions M, Galland F, Bazin H, et al. (1997). "Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing". Immunity. 5 (5): 391–405. doi:10.1016/S1074-7613(00)80496-3. PMID 8934567.
Maras B, Barra D, Dupré S, Pitari G (1999). "Is pantetheinase the actual identity of mouse and human vanin-1 proteins?". FEBS Lett. 461 (3): 149–52. doi:10.1016/S0014-5793(99)01439-8. PMID 10567687. S2CID 25738323.
Martin F, Malergue F, Pitari G, et al. (2001). "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes". Immunogenetics. 53 (4): 296–306. doi:10.1007/s002510100327. PMID 11491533. S2CID 10763223.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kristiansen TZ, Bunkenborg J, Gronborg M, et al. (2005). "A proteomic analysis of human bile". Mol. Cell. Proteomics. 3 (7): 715–28. doi:10.1074/mcp.M400015-MCP200. PMID 15084671.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Min-Oo G, Fortin A, Pitari G, et al. (2007). "Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus". J. Exp. Med. 204 (3): 511–24. doi:10.1084/jem.20061252. PMC 2137903. PMID 17312006.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112299 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037440 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9790769-5] Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P (Dec 1998). "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6". Genomics. 53 (2): 203–13. doi:10.1006/geno.1998.5481. PMID 9790769.

[entrez-6] "Entrez Gene: VNN1 vanin 1".

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Speedway

VNN1

References

Further reading