Protein-coding gene in the species Homo sapiens
Vesicular glutamate transporter 3 (VGLUT3 ) is a protein that in humans is encoded by the SLC17A8 gene .[ 5]
Function This gene encodes a vesicular glutamate transporter . The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft .[ 5]
Clinical significance Mutations in this gene are the cause of autosomal-dominant nonsyndromic deafness type 25 (DFNA25).[ 6] [ 7]
References
Further reading
Greene CC, McMillan PM, Barker SE, et al. (2001). "DFNA25, a novel locus for dominant nonsyndromic hereditary hearing impairment, maps to 12q21-24" . Am. J. Hum. Genet . 68 (1): 254– 60. doi :10.1086/316925 . PMC 1234922 PMID 11115382 . Fremeau RT; Voglmaier S; Seal RP; Edwards RH (2004). "VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate". Trends Neurosci . 27 (2): 98– 103. doi :10.1016/j.tins.2003.11.005 . PMID 15102489 . S2CID 16619295 . Seal RP; Edwards RH (2006). "The diverse roles of vesicular glutamate transporter 3". Neurotransmitter Transporters . Handbook of Experimental Pharmacology. Vol. 175. pp. 137– 50. doi :10.1007/3-540-29784-7_7 ISBN 3-540-29783-9 . PMID 16722234 . Ruel J, Emery S, Nouvian R, et al. (2008). "Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice" . Am. J. Hum. Genet . 83 (2): 278– 92. doi :10.1016/j.ajhg.2008.07.008 . PMC 2495073 PMID 18674745 . Almqvist J, Huang Y, Laaksonen A, et al. (2007). "Docking and homology modeling explain inhibition of the human vesicular glutamate transporters" . Protein Sci . 16 (9): 1819– 29. doi :10.1110/ps.072944707 . PMC 2206968 PMID 17660252 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gong J, Jellali A, Mutterer J, et al. (2006). "Distribution of vesicular glutamate transporters in rat and human retina". Brain Res . 1082 (1): 73– 85. doi :10.1016/j.brainres.2006.01.111 . PMID 16516863 . S2CID 2868346 . Linke N; Bódi N; Resch BE; et al. (2008). "Developmental pattern of three vesicular glutamate transporters in the myenteric plexus of the human fetal small intestine". Histol. Histopathol . 23 (8): 979– 86. PMID 18498073 . Takamori S; Malherbe P; Broger C; Jahn R (2002). "Molecular cloning and functional characterization of human vesicular glutamate transporter 3" . EMBO Rep . 3 (8): 798– 803. doi :10.1093/embo-reports/kvf159 . PMC 1084213 PMID 12151341 . This article incorporates text from the United States National Library of Medicine , which is in the public domain .
By group
SLC1–10
(1): (2): (3): (4): (5): (6): (7): (8): (9): (10):
SLC11–20
(11): (12): (13): (14): (15): (16): (17): (18): (19): (20):
SLC21–30
(21): (22): (23): (24): (25): (26): (27): (28): (29): (30):
SLC31–40
(31): (32): (33): (34): (35): (36): (37): (38): (39): (40):
SLC41–48
(41): (42): (43): (44): (45): (46): (47): (48):
Transporter
EAATs Tooltip Excitatory amino acid transporters vGluTs Tooltip Vesicular glutamate transporters
Enzyme
GAH Tooltip Glutamine aminohydrolase (glutaminase) AST Tooltip Aspartate aminotransferase ALT Tooltip Alanine aminotransferase GDH Tooltip Glutamate dehydrogenase GS Tooltip Glutamine synthetase GAD Tooltip Glutamate decarboxylase
