Protein-coding gene in the species Homo sapiens
Rho-related GTP-binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene .[ 5] [ 6]
ARHJ belongs to the Rho family of small GTP-binding proteins . Rho proteins regulate the dynamic assembly of cytoskeletal components for several physiologic processes, such as cell proliferation and motility and the establishment of cell polarity . They are also involved in pathophysiologic process, such as cell transformation and metastasis .[supplied by OMIM][ 6]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000126785 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046768 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Vignal E, De Toledo M, Comunale F, Ladopoulou A, Gauthier-Rouviere C, Blangy A, Fort P (Dec 2000). "Characterization of TCL, a new GTPase of the rho family related to TC10 and Ccdc42" . J Biol Chem . 275 (46): 36457– 64. doi :10.1074/jbc.M003487200 PMID 10967094 . ^ a b "Entrez Gene: RHOJ ras homolog gene family, member J" .
Further reading
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science . 307 (5715): 1621– 5. Bibcode :2005Sci...307.1621B . doi :10.1126/science.1105776 . PMID 15761153 . S2CID 39457788 . Nishikimi A, Meller N, Uekawa N, et al. (2005). "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes". FEBS Lett . 579 (5): 1039– 46. doi :10.1016/j.febslet.2005.01.006 . PMID 15710388 . S2CID 36721405 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ruusala A, Aspenström P (2004). "Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology" . FEBS Lett . 572 (1– 3): 159– 66. doi :10.1016/j.febslet.2004.06.095 PMID 15304341 . S2CID 9107914 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . de Toledo M, Senic-Matuglia F, Salamero J, et al. (2004). "The GTP/GDP Cycling of Rho GTPase TCL Is an Essential Regulator of the Early Endocytic Pathway" . Mol. Biol. Cell . 14 (12): 4846– 56. doi :10.1091/mbc.E03-04-0254 . PMC 284789 PMID 12960428 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 .
