HOXA7

HOXA7
Identifiers
Aliases	HOXA7, ANTP, HOX1, HOX1.1, HOX1A, homeobox A7
External IDs	OMIM: 142950; MGI: 96179; HomoloGene: 56001; GeneCards: HOXA7; OMA:HOXA7 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	27,157,936 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	52,198,834 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	3204
	15404
	ENSG00000122592
	ENSMUSG00000038236
	P31268
	P02830
	NM_006896
	NM_010455
	NP_008827
	NP_034585
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.^[5]^[6]^[7]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122592 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038236 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
^ Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–553. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
^ ^a ^b "Entrez Gene: HOXA7 homeobox A7".

Balling R, Mutter G, Gruss P, Kessel M (July 1989). "Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice". Cell. 58 (2): 337–347. doi:10.1016/0092-8674(89)90848-9. hdl:11858/00-001M-0000-002C-3E33-1. PMID 2568891. S2CID 43658121.
Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, et al. (December 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–10402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–756. doi:10.1139/g89-133. PMID 2576652.
Verlinsky Y, Morozov G, Gindilis V, Strom CM, Freidin M, Rechitsky S, et al. (June 1995). "Homeobox gene expression in human oocytes and preembryos". Molecular Reproduction and Development. 41 (2): 127–132. doi:10.1002/mrd.1080410202. PMID 7654365. S2CID 43123886.
Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1–2): 114–115. doi:10.1159/000134320. PMID 8646877.
Knoepfler PS, Calvo KR, Chen H, Antonarakis SE, Kamps MP (December 1997). "Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14553–14558. Bibcode:1997PNAS...9414553K. doi:10.1073/pnas.94.26.14553. PMC 25052. PMID 9405651.
Min W, Woo HJ, Lee CS, Lee KK, Yoon WK, Park HW, et al. (March 1998). "307-bp fragment in HOXA7 upstream sequence is sufficient for anterior boundary formation". DNA and Cell Biology. 17 (3): 293–299. doi:10.1089/dna.1998.17.293. PMID 9539109.
McIlhatton MA, Bremner P, McMullin MF, Maxwell AP, Winter PC, Lappin TR (November 1998). "Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1442 (2–3): 329–333. doi:10.1016/s0167-4781(98)00170-5. PMID 9804983.
Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, et al. (March 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–3496. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Kim MH, Jin H, Seol EY, Yoo M, Park HW (January 2000). "Sequence analysis and tissue specific expression of human HOXA7". Molecular Biotechnology. 14 (1): 19–24. doi:10.1385/MB:14:1:19. PMID 10911612. S2CID 25333474.
La Celle PT, Polakowska RR (August 2001). "Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation". The Journal of Biological Chemistry. 276 (35): 32844–32853. doi:10.1074/jbc.M104598200. PMID 11435435.
Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, et al. (February 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
Bertrand FE, Spengeman JD, Shah N, LeBien TW (December 2003). "B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression". Leukemia. 17 (12): 2454–2459. doi:10.1038/sj.leu.2403178. PMID 14562113.