DKE may refer to:

• DKE Records, a record label associated with Hall & Oates
• Data & Knowledge Engineering, an academic journal
• Delta Kappa Epsilon, an American student organization
• German Commission for Electrotechnical, Electronic & Information Technologies of DIN and VDE, a German standards organization
• The Dunning–Kruger effect, a form of cognitive bias which causes people with limited competence to overrate their understanding and abilities.
• Dresden-Kemnitz station (DS100 code), a railway station in Dresden, Germany
• Deutscher Kleinempfänger, a brand of early Volksempfänger, a type of radio
• Department of Data Science and Knowledge Engineering, at Maastricht University, Netherlands
• Dihakho Station (station code), a railway station in Assam, India
• Jubilee Airways (ICAO code), a British airline