Protein-coding gene in humans
Death effector domain containing protein is a protein that in humans is encoded by the DEDD gene .[ 5] [ 6] [ 7]
Function This gene encodes a protein that contains a death effector domain (DED). DED is a protein–protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis . Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF , a basal factor required for RNA polymerase I transcription, in the nucleolus . At least three transcript variants encoding the same protein have been found for this gene.[ 7]
Interactions DEDD has been shown to interact with:
References
^ a b c GRCh38: Ensembl release 89: ENSG00000158796 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013973 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME (Dec 1998). "DEDD, a novel death effector domain-containing protein, targeted to the nucleolus" . EMBO J . 17 (20): 5974– 86. doi :10.1093/emboj/17.20.5974 . PMC 1170924 PMID 9774341 . ^ Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ (Dec 1998). "DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells" . Endocrinology . 139 (12): 4839– 48. doi :10.1210/endo.139.12.6335 PMID 9832420 . ^ a b "Entrez Gene: DEDD death effector domain containing" .^ a b Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (Apr 2002). "Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC" . Cell Death Differ . 9 (4): 439– 47. doi :10.1038/sj.cdd.4401038 PMID 11965497 . ^ a b Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC (Mar 2002). "Identification and characterization of DEDD2, a death effector domain-containing protein" . J. Biol. Chem . 277 (9): 7501– 8. doi :10.1074/jbc.M110749200 PMID 11741985 . ^ Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME (Oct 1998). "DEDD, a novel death effector domain-containing protein, targeted to the nucleolus" . EMBO J . 17 (20): 5974– 86. doi :10.1093/emboj/17.20.5974 . PMC 1170924 PMID 9774341 . ^ Alcivar A, Hu S, Tang J, Yang X (Jan 2003). "DEDD and DEDD2 associate with caspase-8/10 and signal cell death" . Oncogene . 22 (2): 291– 7. doi :10.1038/sj.onc.1206099 PMID 12527898 .
Further reading
Park MY, Ryu SW, Kim KD, Lim JS, Lee ZW, Kim E (2005). "Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation" . Int. J. Cancer . 115 (3): 412– 8. doi :10.1002/ijc.20857 PMID 15688372 . Alcivar A, Hu S, Tang J, Yang X (2003). "DEDD and DEDD2 associate with caspase-8/10 and signal cell death" . Oncogene . 22 (2): 291– 7. doi :10.1038/sj.onc.1206099 PMID 12527898 . Lee JC, Schickling O, Stegh AH, Oshima RG, Dinsdale D, Cohen GM, Peter ME (2002). "DEDD regulates degradation of intermediate filaments during apoptosis" . J. Cell Biol . 158 (6): 1051– 66. doi :10.1083/jcb.200112124 . PMC 2173221 PMID 12235123 . Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (2002). "Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC" . Cell Death Differ . 9 (4): 439– 47. doi :10.1038/sj.cdd.4401038 PMID 11965497 . Schickling O, Stegh AH, Byrd J, Peter ME (2002). "Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription" . Cell Death Differ . 8 (12): 1157– 68. doi :10.1038/sj.cdd.4400928 PMID 11753564 . Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC (2002). "Identification and characterization of DEDD2, a death effector domain-containing protein" . J. Biol. Chem . 277 (9): 7501– 8. doi :10.1074/jbc.M110749200 PMID 11741985 .
