Chandrasekaran is a surname. Notable people with the surname include:

• A. Chandrasekaran, Indian politician and former Member of the Legislative Assembly of Tamil Nadu
• Chidambara Chandrasekaran, (1911–2000), Indian demographer and statistician
• Durai Chandrasekaran, Indian politician and incumbent Member of the Legislative Assembly of Tamil Nadu
• K. B. V. Sc. Chandrasekaran, Indian politician and incumbent Member of the Legislative Assembly of Tamil Nadu
• K N Chandrasekaran Pillai, Indian legal academic
• M. Chandrasekaran, Carnatic classical violinist from Chennai (formerly Madras), Tamil Nadu
• Natarajan Chandrasekaran, (born June 1963), Indian business executive, Chairman of Tata Sons
• Periyasamy Chandrasekaran (1957–2010), Sri Lankan politician
• Rajiv Chandrasekaran, Indian-American journalist
• S. Chandrasekaran (born 1959), contemporary modern artist

• Chandrasekhar (disambiguation)
• Chandrasekharania