Arsinoe (Ancient Greek: Ἀρσινόη, romanized: Arsinóē), meaning "elevated mind", may refer to:

• Arsinoe of Macedon, mother of Ptolemy I Soter
• Apama II or Arsinoe (c. 292 BC–after 249 BC), wife of Magas of Cyrene and mother of Berenice II
• Arsinoe, probable mother of Lysimachus or his first wife Nicaea of Macedon
• Arsinoe I (305 BC–247 BC) of Egypt
• Arsinoe II (316 BC–270 BC) of Egypt
• Arsinoe III of Egypt (c. 246 BC–204 BC)
• Arsinoe IV of Egypt (died 41 BC), half-sister of Cleopatra VII
• Arsinoe (mythology), name of multiple mythological figures

• Arsinoe (Cilicia)
• Arsinoe (Crete)
• Arsinoe (Northwest Cyprus)
• Arsinoe (Southwest Cyprus)
• Arsinoe (Gulf of Suez), a port of Egypt
• Arsinoe (Eritrea)
• Conope (Greece) or Arsinoe
• Ephesus, also called Arsinoe
• Faiyum (Egypt), also called Arsinoe or Crocodilopolis, seat of the Roman Catholic titular bishopric Arsinoë in Arcadia
• Famagusta (Cyprus) or Arsinoe
• Coressia (Greece), called Arsinoe in the Hellenistic period
• Methana (Greece), called Arsinoe in the Ptolemaic period
• Olbia (Egypt) or Arsinoe
• Patara (Lycia) or Arsinoe
• Taucheira (Libya) or Arsinoe
• Arsinoes Chaos, located in the Margaritifer Sinus quadrangle on Mars

• Arsinoe, a character in Le Misanthrope by Molière
• Arsinoe, a character in The Etruscan by Mika Waltari
• Arsinoe, a character in Three Dark Crowns by Kendare Blake
• Arsinoe, Queen of Cyprus, a 1705 English opera

• Arsinoe (beetle), a genus of beetles in the family Carabidae
• 404 Arsinoë, an asteroid

• Arsinoi, a community in Messenia