The freestyle relay events at the 2022 World Para Swimming Championships were held at the Penteada Olympic Swimming Complex in Madeira between 12–18 June.

Event	Gold	Silver	Bronze
Mixed 4x50m freestyle relay 20pts	Brazil[1] Lidia Vieira da Cruz Daniel Xavier Mendes Joana Maria da Silva Neves Euzébio Samuel da Silva de Oliveira Patrícia Pereira dos Santos	Mexico[1] Nely Edith Miranda Herrera Vianney Marlen Trejo Delgadillo Ángel de Jesús Camacho Ramírez Juan Jose Gutierrez Bermudez Karina Amayrani Hernandez Torres Cristopher Gregorio Tronco Sánchez	Italy Giulia Ghiretti Monica Boggioni Luigi Beggiato Antonio Fantin
Mixed 4x100m freestyle relay 34pts[1]	Italy Giulia Terzi Xenia Francesca Palazzo Simone Barlaam Stefano Raimondi Antonio Fantin Riccardo Menciotti Alessia Scortechini	United States McKenzie Coan Audrey Kim Robert Griswold Jamal Hill Elizabeth Smith Morgan Stickney Matthew Torres	Spain Iñigo Llopis Sanz Sarai Gascón Nahia Zudaire Borrezo Ariel Enrique Schrenck Martinez Jacobo Garrido Brun Núria Marquès Soto
Mixed 4x100m freestyle relay 49pts[1]	Brazil Matheus Rheine Douglas Matera Lucilene da Silva Sousa Maria Carolina Gomes Santiago	Spain José Ramón Cantero Elvira María Delgado Nadal Ivan Salguero Oteiza Marian Polo López	Great Britain Hannah Russell Matthew Redfern Scarlett Humphrey Stephen Clegg
Mixed 4x100m freestyle relay S14[1]	Great Britain Thomas Hamer Bethany Firth Jessica-Jane Applegate Reece Dunn	Australia Jack Ireland Benjamin Hance Ruby Storm Madeleine McTernan	Brazil Gabriel Bandeira Ana Karolina Soares de Oliveira [pt] Débora Borges Carneiro Joao Pedro Brutos de Oliveira

Mixed 4x50m Freestyle Relay 20pts Finals^[1]

Seven nations took part.^[2]

Rank	Lane	Nation	Swimmers	Time	Notes
	4	Brazil	Lidia Vieira da Cruz Daniel Xavier Mendes Joana Maria da Silva Neves Euzébio Samuel da Silva de Oliveira	2:20.40	AM
	7	Mexico	Nely Edith Miranda Herrera Vianney Marlen Trejo Delgadillo Ángel de Jesús Camacho Ramírez Juan Jose Gutierrez Bermudez	2:32.74
	3	Italy	Giulia Ghiretti Monica Boggioni Luigi Beggiato Antonio Fantin	2:39.75
4	5	Great Britain	Maisie Summers-Newton William Perry Lyndon Longhorne Ellie Challis	2:40.95
5	2	Spain	Miguel Luque Javier Torres Nahia Zudaire Borrezo Marta Fernández Infante	2:41.55
6	6	Greece	Alexandra Stamatopoulou Alexandros-Stylianos Lergios Antonios Tsapatakis Maria Tsakona	2:48.04
7	1	Canada	Shelby Newkirk Felix Cowan Jordan Tucker Jacob Brayshaw	3:51.68

Mixed 4x100m Freestyle Relay 34pts Finals^[1]

Rank	Lane	Nation	Swimmers	Time	Notes
	4	Italy	Giulia Terzi Xenia Francesca Palazzo Simone Barlaam Stefano Raimondi	4:02.53	WR
	5	United States	McKenzie Coan Audrey Kim Robert Griswold Jamal Hill	4:09.81
	3	Spain	Iñigo Llopis Sanz Sarai Gascón Nahia Zudaire Borrezo Ariel Enrique Schrenck Martinez	4:10.66
4	6	Great Britain	Tully Kearney James Hollis Toni Shaw Oliver Carter	4:11.52
5	7	Canada	Felix Cowan Shelby Newkirk Alexander Elliot Aurélie Rivard	4:11.82
6	2	Brazil	Mariana Ribeiro Cecília Kethlen Jerônimo de Araújo Daniel Xavier Mendes Phelipe Andrews Melo Rodrigues	4:12.06
7	1	Australia	Rachael Watson Rowan Crothers William Martin Jasmine Greenwood	4:20.06
8	8	Argentina	Iñaki Basiloff Daniela Giménez Maria Jazmin Aragon Diani Nicolas Matias Nieto	4:31.36

Mixed 4x100m Freestyle Relay 49pts Finals^[1]

Rank	Lane	Nation	Swimmers	Time	Notes
	4	Brazil	Matheus Rheine Douglas Matera Lucilene da Silva Sousa Maria Carolina Gomes Santiago	3:54.26
	5	Spain	José Ramón Cantero Elvira María Delgado Nadal Ivan Salguero Oteiza Marian Polo López	3:59.02
	6	Great Britain	Hannah Russell Matthew Redfern Scarlett Humphrey Stephen Clegg	4:08.60
4	3	Japan	Uchu Tomita Genki Saito Ayano Tsujiuchi Ono Chikako	4:13.72

Mixed 4x100m Freestyle Relay S14 Finals^[1]

Rank	Lane	Nation	Swimmers	Time	Notes
	4	Great Britain	Thomas Hamer Bethany Firth Jessica-Jane Applegate Reece Dunn	3:44.03
	5	Australia	Jack Ireland Benjamin Hance Ruby Storm Madeleine McTernan	3:48.36
	3	Brazil	Gabriel Bandeira Ana Karolina Soares de Oliveira [pt] Débora Borges Carneiro Joao Pedro Brutos de Oliveira	3:49.93	AM
4	2	Canada	Nicholas Bennett Tyson MacDonald Angela Marina Emma Van Dyk	3:58.43
5	6	Japan	Naohide Yamaguchi Anku Matsuda Kasumi Fukui Mami Inoue	3:59.72