Yousaf Khan or similar may refer to:

• Yusaf Khan (general) (born 1948), former Pakistan Army general and vice chief of army staff
• Yusuf Husain Khan (1902–1976), historian, scholar and author
• Yousuf Khan (actor) (died 2009), Pakistani film actor
• Yousuf Khan (cricketer) (born 2002), Afghan cricketer
• Yousuf Khan (footballer) (1937–2006), former Indian soccer player
• Yousuf Khan (Pakistani politician), member of the National Assembly of Pakistan from Khyber Pakhtunkhwa (2024–2029)
• Yusuf Khan (actor) (died 1985), Indian actor, father of actor Faraz Khan
• Yousaf Ali Khan, British film director
• Mohammad Yusuf Khan (disambiguation), several people

• Yusuf Khan and Sherbano, Pashtun folktale
• Yusuf Khan (comics), father of Kamala Khan in Marvel Comics
  • Yusuf Khan (Marvel Cinematic Universe), from Ms. Marvel and The Marvels
• Yusef Khan, from EastEnders

• Yusef Khan, Iran, village in Iran