XDR may refer to:

• XDR (audio) or eXtended Dynamic Range, a quality-control system for pre-recorded audio cassettes
• XDR (video game), for the Sega Mega Drive
• XDR DRAM, a type of computer memory
• XDR Schema, a discontinued schema language for XML documents
• External Data Representation, a data interoperability format
• Extensively drug-resistant, a category of multiple drug resistance
• Special drawing rights, a monetary unit of the International Monetary Fund (ISO 4217 currency code XDR)
• Extended detection and response, a cyber security technology that monitors and mitigates cyber security threats
• Extreme Dynamic Range, a designation for some computer monitors from Apple, like Pro Display XDR, Super Retina XDR, Liquid Retina XDR, and Ultra Retina XDR