Wolfram may refer to:

• Wolfram (name), a Germanic masculine given name and a surname (includes a list of people with the name)
• Wolfram (musician), an Austrian DJ
• Wolfram (element), the original name for the chemical element best known as tungsten
• Wolfram Research, a software company known for the symbolic computation program Mathematica
  • Wolfram Language, the programming language used by Mathematica
  • Wolfram code, a naming system for one-dimensional cellular automaton rules introduced by Stephen Wolfram
• Wolfram syndrome, a genetic disorder
• Wolfram, Queensland, a former mining town in Australia
• The Wolfram, a fictional military airship in the air combat video game The Sky Crawlers: Innocent Aces