William or Bill Wilkinson may refer to:

• William Alexander Wilkinson (1892–1983), Australian born British soldier and cricketer
• William Arthur Wilkinson (1795–1865), British Member of Parliament (MP) for Lambeth 1852–57
• William Wilkinson (diplomat) (died 1836), British Consul to Wallachia and Moldavia
• William Wilkinson (architect) (1819–1901), Gothic Revival architect who practised in Oxford
• William Cleaver Wilkinson (1833–1920), American Baptist minister and professor
• William Henry Wilkinson (1858–1930), British Sinologist who served as Consul-General for H.B.M in China and Korea in the 19th century
• William Henry Wilkinson (trade unionist) (1850–1906), British trade union leader
• William Wilkinson (New South Wales politician) (1858–1946), Australian politician and doctor
• William Wilkinson (cricketer, born 1857) (1857–1946), Australian-born physician and cricketer who played in England
• William Wilkinson (cricketer, born 1859) (1859–1940), English cricketer
• William Wilkinson (cricketer, born 1881) (1881–1961), English cricketer and footballer
• William Wilkinson (Australian cricketer) (1899–1974), Australian cricketer
• William Wilkinson (footballer), goalkeeper active in England in the 1890s
• William Wilkinson (priest) (1897–?), Anglican priest
• William Birkinshaw Wilkinson (1854–1927), member of the Royal Geographical Society
• Bill Wilkinson (ice hockey) (born 1947), Canadian college ice hockey coach
• Bill Wilkinson (baseball) (born 1964), American baseball player
• Bill Wilkinson (athlete) (born 1934), English athlete
• Bill Wilkinson (Ku Klux Klan) (born 1942)