William Howe may refer to:

• William Howe, 5th Viscount Howe (1729–1814), British general during American Revolutionary War
• William Howe (architect) (1803–1852), patented Howe truss for covered bridges
• William Howe (mayor) (1864–1952), newspaperman in Victoria, Australia
• William B. W. Howe (1824–1894), Bishop of South Carolina
• William Dean Howe (1916–1982), Canadian Member of Parliament
• William F. Howe (lawyer) (1828–1902), American trial lawyer, founded Howe and Hummel
• William F. Howe (general) (1888–1952), American stockbroker and military leader during World Wars
• William H. Howe (1837–1907), American Union Army soldier during the Civil War and Medal of Honor recipient
• William Henry Howe (1846–1929), American painter
• William T. Howe (1835–1918), farmer and political figure in New Brunswick, Canada
• William Wirt Howe (1833–1909), Justice of the Louisiana Supreme Court
• Bill Howe (1922–2007), baseball player at Yale University
• W. B. W. Howe Jr., (1851-1912), architect, son of the bishop

• Will D. Howe (1873–1946), American educator, editor, and writer