William Cross may refer to:

• Bill Cross (1917–2015), British soldier
• Billy Cross (American football) (1929–2013), American football playerv
• Billy Cross (born 1946), American guitarist, singer and producer

• William Cross (politician) (1856–1892), British Member of Parliament for Liverpool West Derby, 1888–1893
• William Cross (rower) (1908–1993), Australian Olympic rower
• William Cross (rugby union) (1851–1890), Scottish rugby union player and referee
• William E. Cross Jr. (born 1940), professor at the CUNY Graduate Center

• Will Cross, American mountain climber
• Willie Cross (1883–1949), Scottish footballer
• The pseudonym of John Williams (convict), transported to Van Diemen's Land