William Bourne may refer to:

• William Bourne (MP of Bedford) (by 1499–1545), MP for Bedford
• William Bourne of Derby, MP for Derby in 1297

• William Bourne (mathematician) (1535–1582), English mathematician
• William Bourne (19th century businessman), see Denby Pottery Company
• William Oland Bourne (1819–1901) American clergyman, journalist, social reformer
• Bill Bourne (cricketer) (born 1952), Barbadian cricketer
• Bill Bourne (1954–2022), Canadian musician and songwriter