William Osborne or Osborn may refer to:

• William Osborne (umpire), National League umpire in 1876
• William H. Osborne (born 1960), president and CEO of Federal Signal Corporation
• William Osborne (writer) (born 1960), English writer
• William G. Osborne, respondent in District Attorney's Office v. Osborne, a U.S. Supreme Court case
• Will Osborne (rugby) (1875–?), Welsh rugby player
• Qwominer William Osborne, British Virgin Islands politician
• William Osborn (Medal of Honor) (1837–1887), American soldier and Medal of Honor recipient
• William A. Osborn (born 1947), American bank executive
• William Church Osborn (1862–1951), New York State Democratic Committee Chairman, 1914–1916
• William H. Osborn (1821–1894), American railroad tycoon
• Sir William Osborne, 8th Baronet (?–1783), Irish baronet and politician
• William Evelyn Osborn (1868–1906), British artist
• Bill Osborne (born 1955), New Zealand rugby player
• Will Osborne (singer) (1905–1981), Canadian singer

• William Osbourne (disambiguation)