Wazir Khan was a title bestowed by Mughal emperors, and may refer to:

• Wazir Khan (Lahore) (17th century), governor of Lahore
  • Wazir Khan Mosque, a mosque in Lahore commissioned by Khan when he was court physician
• Wazir Khan (Sirhind) (1635–1710), governor of Sirhind
• Wazir Ali Khan (1780–1817), fourth nawab wazir of Oudh
• Wazir Akbar Khan (1816–1845), Afghan prince
  • Wazir Akbar Khan, Kabul, a neighbourhood of Kabul named after the Afghan prince
• Muhammad Wazir Khan (1834–1864), the second ruler of the princely state of Tonk
• Wazir Arsala Khan (19th century), Afghan politician
• Wazir Khan (Rampur) (1860–1926), chief musician of Rampur State and a descendant of Naubat Khan

• Wazir Khanum, Mughal princess, mother of 19th-century Indian Urdu poet Daagh Dehlvi
• Wazir (disambiguation)
• Khan (title)
• Khan (surname)