Wasco is the name of four places in the United States:

• Wasco, California, a city in California
  • Wasco State Prison, located in Wasco, California
• Wasco, Illinois, a former hamlet (unincorporated town) in Illinois, now part of Campton Hills
• Wasco, Oregon, a city in Oregon
• Wasco County, Oregon, a county in Oregon

• Wasco a city in Chile
• Wasco a province in Chile

Wasco may also mean:

• Wasco-Wishram, two Native American tribes from Oregon
• Wasco-Wishram language, a dialect of Upper Chinook, a Chinookan language

• Wasco Energy, an oil and gas service company specializing in pipeline coatings