Vasopressin analogue
| Vasopressin analogue | |
|---|---|
| Drug class | |
 Vasopressin | |
| Class identifiers | |
| Use | Diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, etc. |
| ATC code | H01BA |
| Biological target | Vasopressin receptor |
| Legal status | |
| In Wikidata | |
Vasopressin analogues are synthetic peptides structurally and functionally similar to arginine vasopressin (AVP), a naturally occurring hormone in mammals. These compounds have been developed to target specific vasopressin receptors (V1, V2, and V3) with varying affinities, allowing for more tailored therapeutic applications. These analogues have been developed to address limitations of endogenous vasopressin, such as short half-life and lack of receptor selectivity, and to potentially reduce side effects associated with non-selective vasopressin receptor activation.[1][2]
Medical uses
The most prominent vasopressin analogues include desmopressin (dDAVP), terlipressin, and selepressin, each with distinct pharmacological profiles and clinical uses. Desmopressin, a V2 receptor agonist, is primarily used for treating diabetes insipidus and certain bleeding disorders.[3] Terlipressin, with higher V1 receptor selectivity, has found applications in managing variceal bleeding and hepatorenal syndrome. Selepressin, a selective V1 receptor agonist, has been investigated for its potential in treating septic shock.[1][2]
Research
Ongoing research continues to explore the therapeutic potential of vasopressin analogues in various clinical conditions, particularly in the management of shock states and fluid balance disorders.[1][2]
They are also used in cirrhosis patients.[4]
References
- ^ a b c Glavaš M, Gitlin-Domagalska A, Dębowski D, Ptaszyńska N, Łęgowska A, Rolka K (March 2022). "Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides". International Journal of Molecular Sciences. 23 (6): 3068. doi:10.3390/ijms23063068. PMC 8955888. PMID 35328489.
- ^ a b c Demiselle J, Fage N, Radermacher P, Asfar P (January 2020). "Vasopressin and its analogues in shock states: a review". Annals of Intensive Care. 10 (1): 9. doi:10.1186/s13613-020-0628-2. PMC 6975768. PMID 31970567.
- ^ "Desmopressin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD". www.webmd.com. Retrieved 2022-11-10.
- ^ Myc LA, Stine JG, Chakrapani R, Kadl A, Argo CK (January 2017). "Vasopressin use in critically ill cirrhosis patients with catecholamine-resistant septic shock: The CVICU cohort". World Journal of Hepatology. 9 (2): 106–113. doi:10.4254/wjh.v9.i2.106. PMC 5241528. PMID 28144392.