Vandzene is a village in Vandzene parish, Talsi Municipality, in the western part of Latvia. The community's elevation is 49 m (160 ft).

The Vandzene Manor was built at the start of the 19th century. At present, Vandzene Gymnasium occupies the estate.

The grand-stone of Vandzene, with a circumference of 26 metres, is the third largest stone in Latvia. In ancient times it was a place of worship and stood amid an apple orchard and birch grove.

57°20′N 22°48′E / 57.333°N 22.800°E / 57.333; 22.800