After moving into their new house, Casey decides she needs a room of her own - or rather, she wants Derek's room.

Casey trips at school and is given the nickname "Klutzilla" by Derek.

Casey and Derek try to convince their parents that they can be trusted to take care of Lizzie and Edwin for the weekend.

Casey, Lizzie and Nora decide to add a feminine touch to the living room.

Casey tries to change her reputation by teaming up with the school's biggest slacker for an English project - Derek, who's struggling to pass for once.

Casey volunteers to organize the wedding reception for her aunt, however, she must deal with the constant criticism from her nemesis, cousin Vicki.

Casey helps Derek with his "merchandising business" while he has the chicken pox, which George attempts to avoid getting himself.

The game is on, and Casey and Derek face off for the prized areas of the house.

Casey tries to ruin Derek's babysitting date with Sandra by leaving him alone with Marti the Monster.

When Derek causes Casey to sprain her ankle, she schemes to take one of his prized possessions.

Casey tries to fight sexist attitudes at home by going after the video game Babe Raider.

Casey attempts to organize the household chores, while Nora tries to repair her relationship with the neighbors.

Derek tries to ruin the budding romance between Casey and his best friend, Sam.

Casey believes that Derek is taking revenge on her by asking Emily out on a date; Lizzie worries about being a bad dancer.

Derek agrees to train Lizzie in the art of playing hockey; Casey coaches Edwin on how to talk to girls; George and Nora find out Marti is stealing toys from other kids.

Derek is worried that Casey and Sam's break-up will stop him from playing in the Hockey Championships in Sweden.

Casey convinces Derek to run for school president; Lizzie tries to force the family to be more environmentally aware.

Derek swallows his pride and asks Casey to join his band for the annual "Battle of the Bands" competition.

Using Derek's advice, Casey lies to get an extension on a school assignment.

Lizzie has a crush on Casey's new boyfriend, who Marti dislikes, however, Derek learns a devastating secret. George becomes upset when Nora says their relationship was not love at first sight.

Casey tries to pay Derek back for his practical jokes by pulling a prank of her own.

Casey's dance competition and Derek's hockey playoffs stress them out, much to the chagrin of Lizzie and Edwin.

Casey bets Derek that she can get a guy to ask her out on a date.

Derek starts to act like a grown-up when Casey tells him that a girl finds him immature. Meanwhile, mice are found in the house, scaring the men, but Lizzie refuses to let them be exterminated.

Missing her dad, who is currently based in New York, Casey invites him to dinner and sets out to make the night perfect.

Derek and Kendra try to find the perfect date for Casey.

Derek asks out Casey's friend even though he has a girlfriend.

George and Nora plan a joint birthday party for Lizzie and Edwin.

While the parents are out, Casey babysits and tries to be very responsible, however, Derek is completely against her.

Nora becomes a stay-at-home mom and tries to recruit Casey and her friends to work at the school fun fair.

Derek is selected to be a prefect at school, but an unhappy Casey tries to prove that he is not up to the job. Meanwhile, Edwin and Lizzie realize Marti always gets what she wants.

Casey and Derek both end up getting a job at the same restaurant working as waiters. Meanwhile, Edwin and Lizzie revel in being the oldest children in the house.

Edwin is getting bullied by a kid at school and asks Derek to do something about it.

Casey attempts to start filming a family documentary for school, but comes across a few problems with the cast.

Casey secures the lead role in the school musical; Derek gets promoted from the chorus to lead vocalist.

Casey works at Marti's summer camp at the high school, while Derek has to go to summer school. Meanwhile, Edwin and Lizzie set up a pet-sitting service at home.

Derek switches test papers with Casey, and then lures her into a scheme that will keep them both out of trouble; Edwin, Lizzie, and Marti feel that they are doing too many chores for the amount of allowance they are getting.

While failing Spanish at school, George and Abby (Derek's mom) think that their son should come live with her in Spain for six months.

When Casey lectures Derek and Edwin about watching scary movies, they take her admonishment as a dare to scare.

Derek is frightened by the fact that he may have to spend his sixteenth birthday with his family, while they try to get him a car.

After his break-up with Kendra, Derek thinks he doesn't want to date ever again - until he meets the new waitress at Smelly Nelly's.

When Christmas plans go awry, Aunt Madge encourages Derek to help restore the family's holiday spirit.

While studying for a test on the great romantic figure Ivanhoe, Casey decides that even in the modern world, there's something noble about a chivalrous guy risking life and limb to protect his loved ones.

Casey accidentally causes Emily and Sheldon to break up; Kendra invites Max to a Valentine's Day dance. Meanwhile, George tries to plan the perfect Valentine's day for Nora, and Edwin discovers the power of rumors.

Derek thinks he has finally caught Sally's attention; Casey thinks it's all over between her and Max.

Derek turns Casey's plan for a sophisticated Sweet Sixteen party into a bash more to his liking, but problems arise when she develops appendicitis.

Despite his past failures, Derek is so confident that he'll pass his driver's test before Casey that he makes her a hefty wager. George, meanwhile, loses his license.

Casey's dream of a romantic prom night turns into a nightmare when Derek accidentally ruins her dress. Meanwhile, Sheldon tries to tell Emily something, and Sally wants to go to prom with Derek.

Casey tries out for the cheerleading squad, despite the fact that Max's ex-girlfriend Amy is the head cheerleader.

Casey develops a mysterious allergic reaction after Max gives her his football jacket; George makes a bet with Derek about his attitude.

Grounded for the weekend for fighting again, Casey and Derek try to sneak out to go to a party, but they end up putting a dent in George's car.

Ever since Sally turned him down a few weeks ago, Derek's been using his patented "freeze out strategy," and it seems to be working.

Derek refuses to help out with Marti's birthday party despite being asked by Sally; Casey tries to find closure after her break-up with Max.

After Derek has trouble expressing his feelings for Sally, she demands that he write a love song for her. Edwin tries out his comedy routine on the family.

After Sally has a friendly dinner with her ex-boyfriend, an irritated Derek decides to spend time with Kendra to make a point that girls and guys can't be just friends.

While the rest of the family heads off to Quebec for March break, Casey and Derek stay home alone together.

Even though she tries not to care, Casey is crushed to learn the cute new guy, Truman, rated her a mere 6 1/2 out of 10.

Derek breaks up with Sally after she reveals her plans to attend a university in another province; believing that he is hurt and bottling up his feelings, a concerned Edwin and Casey try to get him to open up.

Derek plans to drop out of school to be with Sally in Vancouver. All five kids stress about the upcoming school year.

Casey is in panic mode after the diary that details her unsettling romantic dreams about Truman goes missing.

Casey spends the day with George at his law office and takes the initiative to reorganize his filing system. Derek tries to help Nora land a business deal with a wealthy client, despite them both being stuck at home due to the other kids being sick.

Casey gets stuck with Truman as her fencing partner in gym; what starts out as a friendly game of table tennis between Derek and Edwin turns into an ongoing competition to figure out who is the better player.

As George prepares a Mexican fiesta for their second wedding anniversary, Nora gets a reluctant Casey to tell the story of how she and Derek first met.

Ralph stays at Derek's house while his parents are away for the weekend. While there, he develops a crush on Casey.

After entering a TV dance contest, Casey must find a new dance partner when the previous one pairs up with her rival. Meanwhile, Lizzie and Nora try to get George and Edwin to eat healthier.

A surprise visit from Edwin's friend, Teddy, turns into a frequent occurrence that makes the entire household uncomfortable. Despite warnings from Emily, Casey goes on a date with Truman.

Absent: John Ralston as George Venturi

To be eligible for college athletic scholarships, a "D average" Derek seeks help in passing his final exams. Meanwhile, Casey, stressed over finals, tries to relax.

Derek serves as a chaperone for Casey, who is going to a party in Toronto with Truman. Lizzie goes out on a date with a new boy.

Absent: John Ralston as George Venturi

As the prom approaches, Casey and Derek both find themselves without a date; meanwhile, George and Nora have something to tell the family.

Casey is having difficulty writing her valedictorian speech for graduation; Edwin is concerned that he won't be able to live up to Derek's reputation at JS Thompson High when he goes there in the autumn. Casey and Derek accept each other as friends and step-siblings.

Casey and Derek are back and continue their rivalry during a family vacation to visit their grandmother, Felicia at her beautiful lakefront lodge. Things heat up with Casey when she meets Jesse, a young dancer who happens to be a waiter at the lodge. Meanwhile, as Derek is "chilling" on his vacation, he falls for Roxy, the rich girl who lives across the lake. But when Roxy’s father, a greedy land developer, threatens to destroy the natural beauty around them, the McDonald-Venturi kids bond together to save the lake and the lodge, with a little legal help from George and Nora who are having a baby too.

Fifteen to sixteen years after the end of Vacation with Derek, Derek is a rock star with his own band, and single father to teenage Skyler, living in Paris. Meanwhile, Casey is a lawyer, married to a hockey player currently away competing, with three children, teenage Luca and younger Kai and Molly, living in Canada. The family is invited to George and Nora's new home for their twentieth wedding anniversary housewarming party, but only Derek and Casey's families arrive, later joined by Simon, who is on academic probation at university. The family hijinks resume as Skyler and Luca do not get along, Casey and Derek struggle to get the house decorated for their parents' arrival, Simon attempts to write an essay to get off academic probation while also trying to impress a girl in town, and George and Nora, returning from New Jersey, are pursued by a jewel thief due to a mix up when renting a car. It comes to a head when Skyler and Luca hitch a ride to a concert with Simon and get lost, and the family has to pull together to find them, as well as ensure the party goes off without a hitch.