VUF-8430
Names | |
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Preferred IUPAC name 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester[citation needed] | |
Identifiers | |
3D model (JSmol) |
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Abbreviations | VUF-8430 |
ChEMBL | |
ChemSpider | |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C4H11N5S | |
Molar mass | 161.23 g·mol−1 |
log P | -1.367 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
VUF-8430 is a histamine agonist[1] selective for the H4 subtype.[2]
References
- ^ Smith FM, Haskelberg H, Tracey DJ, Moalem-Taylor G (2007). "Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury". Neuroimmunomodulation. 14 (6): 317–25. doi:10.1159/000125048. PMID 18401194. S2CID 23020760.
- ^ Lim, HD; Smits, RA; Bakker, RA; Van Dam, CM; De Esch, IJ; Leurs, R (2006). "Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist". Journal of Medicinal Chemistry. 49 (23): 6650–1. doi:10.1021/jm060880d. PMID 17154494.