VMS may refer to:

• Video management system, most often associated with digital CCTV surveillance
• Voice mail system, an alternate term for voicemail messaging
• An abbreviation for Vietnam Mobile Telecom Services, known as MobiFone
• Variable-message sign, an electronic traffic sign often used on highways
• Virgin mothership, a carrier plane for Virgin Galactic spacecraft (see Virgin Galactic#Motherships)
• Valley Metro system, in Phoenix, Arizona
• Vessel monitoring system, a tracking system for commercial fishing vessels
• The ICAO airline code of His Royal Highness The Crown Prince Maha Vajiralongkorn, a holding airline established under the name of King Rama X of Thailand that maintains legal ownership of his private fleet of aircraft

• OpenVMS or VAX/VMS (Virtual Memory System), a computer operating system
• VMS (Visual Memory System) or VMU (Visual Memory Unit), a storage device for the Sega Dreamcast console
• Vulnerability management solution (or system)
• Vendor management system

• Vail Mountain School, in Colorado
• Vaughn Municipal Schools in New Mexico
• Vallivue Middle School, in the Vallivue School District, Idaho
• Vandenberg Middle School, in the Lompoc Unified School District, California
• Vincent Mary School of Science and Technology, Suvarnabhumi Campus, Assumption University of Thailand
• Vivekananda Mission School, in West Bengal, India

• Visitor Management system for managing the check-in/check-out process for visitors, contractors or staff at premises.
• Vendor management system, for managing vendors or temporary staff
• Volcanogenic massive sulfide ore deposit
• Voluntary milking system, an alternate name for an automatic milking system in dairy farming
• Voynich manuscript, an illustrated codex hand-written in an unknown writing system
• Virginia Motor Speedway
• Vasomotor symptoms, or hot flashes, a symptom of menopause