Umm Isḥāq bint Ṭalḥa ibn ʿUbayd Allāh (Arabic: أم إسحاق بنت طَلحَة بن عُبَيد الله) was the daughter of Talha and one of the wives of Hasan ibn Ali. After his death, she married Hasan's brother, Husayn ibn Ali.

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Umm Ishaq was the daughter of Talha ibn Ubayd Allah. She was reported to be among the most beautiful women of Quraysh.^[1]

Umm Ishaq was one of the wives of Hasan ibn Ali. After Hasan was killed, she married Husayn ibn Ali.^[1] After Husayn was killed, she married Abd Allah ibn Muhammad ibn Abd al-Rahman ibn Abi Bakr. It is said that before this marriage to Abd Allah, she had married Tammam ibn al-Abbas ibn Abd al-Muttalib.^[2]

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Umm Ishaq had three children from Hasan ibn Ali: Husayn (who was known as al-Athram), Talha ibn Hasan, and Fatima bint Hasan.^[3]

She also had one daughter from Husayn: Fatima al-Kubra.^[4] She also bore a daughter, Amina to Abd Allah ibn Muhammad ibn Abd al-Rahman ibn Abi Bakr.^[5]