Umatilla may refer to:

• Umatilla people, a Native American tribe from Oregon
• Umatilla Indian Reservation, an Indian reservation in Oregon
• Umatilla language, a Native American language from the Plateau Penutian group
• Confederated Tribes of the Umatilla Indian Reservation, a Native American tribal entity in the U.S. state of Oregon

• Umatilla County, Oregon, a county in Oregon
• Umatilla, Oregon, a city located in Umatilla County, Oregon
• Umatilla, Florida, a city in Lake County, in the U.S. state Florida

• Umatilla River, a river in Oregon

• Umatilla Chemical Depot, a U.S. Army facility near the city of Umatilla, Oregon