Three vessels of the United States Navy have been named USS San Francisco, after the city of San Francisco, California.

• The first USS San Francisco (C-5) was a protected cruiser commissioned in 1890, converted to a minelayer in 1908, and decommissioned in 1921.
• The second USS San Francisco (CA-38) was a heavy cruiser commissioned in 1934, active throughout the Pacific War, and decommissioned in 1946.
• The third USS San Francisco (SSN-711) is a Los Angeles-class nuclear attack submarine commissioned in 1981 and taken out of active service in 2017.
• The fourth USS San Francisco (SSN-810) will be a Virginia-class nuclear attack submarine, announced in 2023.

• USNS Mission San Francisco (T-AO-123) was an oiler that served in the U.S. Navy from 1947 to 1957.