Protein-coding gene in the species Homo sapiens
Cytochrome b-c1 complex subunit 6, mitochondrial is a protein that in humans is encoded by the UQCRH gene .[ 4] [ 5]
Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex; E.C. 1.10.2.2), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b ) and ten nuclear genes: UQCRC1 , UQCRC2 , Cytochrome c1 , UQCRFS1 (Rieske protein ), UQCRB , "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and "Rieske-associated protein".
References
Further reading
Liu AY, Bradner RC (1993). "Elevated expression of the human mitochondrial hinge protein gene in cancer". Cancer Res . 53 (11): 2460–5. PMID 7684318 . Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene . 150 (2): 243–50. doi :10.1016/0378-1119(94)90433-2 . PMID 7821789 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Modena P, Testi MA, Facchinetti F, et al. (2003). "UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines" . Oncogene . 22 (29): 4586–93. doi :10.1038/sj.onc.1206472 PMID 12881716 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radic. Biol. Med . 37 (12): 2072–81. doi :10.1016/j.freeradbiomed.2004.09.011 . PMID 15544925 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 .
PDB gallery
1bcc : CYTOCHROME BC1 COMPLEX FROM CHICKEN
1be3 : CYTOCHROME BC1 COMPLEX FROM BOVINE
1bgy : CYTOCHROME BC1 COMPLEX FROM BOVINE
1l0l : structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone
1l0n : native structure of bovine mitochondrial cytochrome bc1 complex
1ntk : Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1
1ntm : Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom
1ntz : Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone
1nu1 : Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO)
1pp9 : Bovine cytochrome bc1 complex with stigmatellin bound
1ppj : Bovine cytochrome bc1 complex with stigmatellin and antimycin
1qcr : CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY
1sqb : Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin
1sqp : Crystal Structure Analysis of Bovine Bc1 with Myxothiazol
1sqq : Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS)
1sqv : Crystal Structure Analysis of Bovine Bc1 with UHDBT
1sqx : Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A
2a06 : Bovine cytochrome bc1 complex with stigmatellin bound
2bcc : STIGMATELLIN-BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN
2fyu : Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor
3bcc : STIGMATELLIN AND ANTIMYCIN BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN
