Langbahn Team – Weltmeisterschaft

U7 small nuclear RNA

U7 small nuclear RNA
Predicted secondary structure and sequence conservation of U7
Identifiers
SymbolU7
RfamRF00066
Other data
RNA typeGene; snRNA
Domain(s)Eukaryota
SOSO:0000274
PDB structuresPDBe

The U7 small nuclear RNA (U7 snRNA) is an RNA molecule and a component of the small nuclear ribonucleoprotein complex (U7 snRNP). The U7 snRNA is required for histone pre-mRNA processing.

The 5' end of the U7 snRNA binds the HDE (histone downstream element), a conserved purine-rich region, located 15 nucleotides downstream the histone mRNA cleavage site.[1][2] The binding of the HDE region by the U7 snRNA, through complementary base-pairing, is an important step for the future recruitment of cleavage factors during histone pre-mRNA processing.[3]

See also

References

  1. ^ Spycher C, Streit A, Stefanovic B, Albrecht D, Koning TH, Schümperli D (1994). "3' end processing of mouse histone pre-mRNA: evidence for additional base-pairing between U7 snRNA and pre-mRNA". Nucleic Acids Res. 22 (20): 4023–4030. doi:10.1093/nar/22.20.4023. PMC 331885. PMID 7937126.
  2. ^ Mowry KL, Steitz JA (1987). "Identification of the human U7 snRNP as one of several factors involved in the 3' end maturation of histone premessenger RNA's". Science. 238 (4834): 1682–1687. Bibcode:1987Sci...238.1682M. doi:10.1126/science.2825355. PMID 2825355.
  3. ^ Marzluff, William F.; Wagner, Eric J.; Duronio, Robert J. (2008). "Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail". Nature Reviews Genetics. 9 (11): 843–854. doi:10.1038/nrg2438. PMC 2715827. PMID 18927579.

Further reading

  1. ^ Voigt T, Meyer K, Baum O, Schümperli D (2010). "Ultrastructural changes in diaphragm neuromuscular junctions in a severe mouse model for Spinal Muscular Atrophy and their prevention by bifunctional U7 snRNA correcting SMN2 splicing". Neuromuscul Disord. 20 (11): 744–752. doi:10.1016/j.nmd.2010.06.010. PMID 20832308. S2CID 11835561.
  2. ^ Ruepp MD, Vivarelli S, Pillai RS, Kleinschmidt N, Azzouz TN, Barabino SM, Schümperli D (2010). "The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3'-end processing of animal histone mRNAs". Nucleic Acids Res. 38 (21): 7637–7650. doi:10.1093/nar/gkq613. PMC 2995043. PMID 20634199.
  3. ^ Geib T, Hertel KJ (2009). Valcarcel, Juan (ed.). "Restoration of full-length SMN promoted by adenoviral vectors expressing RNA antisense oligonucleotides embedded in U7 snRNAs". PLOS ONE. 4 (12): e8204. Bibcode:2009PLoSO...4.8204G. doi:10.1371/journal.pone.0008204. PMC 2781471. PMID 19997596.
  4. ^ Godfrey AC, White AE, Tatomer DC, Marzluff WF, Duronio RJ (2009). "The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development". RNA. 15 (9): 1661–1672. doi:10.1261/rna.1518009. PMC 2743060. PMID 19620235.
  5. ^ Yang XC, Torres MP, Marzluff WF, Dominski Z (2009). "Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA". Mol Cell Biol. 29 (15): 4045–4056. doi:10.1128/MCB.00296-09. PMC 2715809. PMID 19470752.
  6. ^ Goyenvalle A, Babbs A, van Ommen GJ, Garcia L, Davies KE (2009). "Enhanced exon-skipping induced by U7 snRNA carrying a splicing silencer sequence: Promising tool for DMD therapy". Mol Ther. 17 (7): 1234–1240. doi:10.1038/mt.2009.113. PMC 2835201. PMID 19455105.
  7. ^ Meyer K, Marquis J, Trüb J, Nlend Nlend R, Verp S, Ruepp MD, Imboden H, Barde I, Trono D, Schümperli D (2009). "Rescue of a severe mouse model for spinal muscular atrophy by U7 snRNA-mediated splicing modulation". Hum Mol Genet. 18 (3): 546–555. doi:10.1093/hmg/ddn382. PMID 19010792.
  8. ^ Marquis J, Kämpfer SS, Angehrn L, Schümperli D (2009). "Doxycycline-controlled splicing modulation by regulated antisense U7 snRNA expression cassettes". Gene Ther. 16 (1): 70–77. doi:10.1038/gt.2008.138. PMID 18701908.
  9. ^ Marz M, Mosig A, Stadler BM, Stadler PF (2007). "U7 snRNAs: a computational survey". Genomics Proteomics Bioinformatics. 5 (3–4): 187–195. doi:10.1016/S1672-0229(08)60006-6. PMC 5054213. PMID 18267300.
  10. ^ Higuchi T, Anzai K, Kobayashi S (2008). "U7 snRNA acts as a transcriptional regulator interacting with an inverted CCAAT sequence-binding transcription factor NF-Y". Biochim Biophys Acta. 1780 (2): 274–281. doi:10.1016/j.bbagen.2007.11.005. PMID 18078822.
  11. ^ Friend K, Lovejoy AF, Steitz JA (2007). "U2 snRNP binds intronless histone pre-mRNAs to facilitate U7-snRNP-dependent 3' end formation". Mol Cell. 28 (2): 240–252. doi:10.1016/j.molcel.2007.09.026. PMC 2149891. PMID 17964263.
  12. ^ Uchikawa H, Fujii K, Kohno Y, Katsumata N, Nagao K, Yamada M, Miyashita T (2007). "U7 snRNA-mediated correction of aberrant splicing caused by activation of cryptic splice sites". J Hum Genet. 52 (11): 891–897. doi:10.1007/s10038-007-0192-8. PMID 17851636.
  13. ^ Marquis J, Meyer K, Angehrn L, Kämpfer SS, Rothen-Rutishauser B, Schümperli D (2007). "Spinal muscular atrophy: SMN2 pre-mRNA splicing corrected by a U7 snRNA derivative carrying a splicing enhancer sequence". Mol Ther. 15 (8): 1479–1486. doi:10.1038/sj.mt.6300200. PMID 17505471.
  14. ^ Asparuhova MB, Marti G, Liu S, Serhan F, Trono D, Schümperli D (2007). "Inhibition of HIV-1 multiplication by a modified U7 snRNA inducing Tat and Rev exon skipping". J Gene Med. 9 (5): 323–334. doi:10.1002/jgm.1027. PMID 17474072. S2CID 26072168.
  15. ^ Scheuerbrandt G (2006). "Exon skipping with U7 gene transfer". Acta Myol. 25 (1): 40–2. PMID 17039980.
  16. ^ Jaeger S, Martin F, Rudinger-Thirion J, Giegé R, Eriani G (2006). "Binding of human SLBP on the 3'-UTR of histone precursor H4-12 mRNA induces structural rearrangements that enable U7 snRNA anchoring". Nucleic Acids Res. 34 (17): 4987–4995. doi:10.1093/nar/gkl666. PMC 1635294. PMID 16982637.
  17. ^ Wagner EJ, Marzluff WF (2006). "ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase". Mol Cell Biol. 26 (17): 6702–6712. doi:10.1128/MCB.00391-06. PMC 1592837. PMID 16914750.
  18. ^ Kolev NG, Steitz JA (2006). "In vivo assembly of functional U7 snRNP requires RNA backbone flexibility within the Sm-binding site". Nat Struct Mol Biol. 13 (4): 347–353. doi:10.1038/nsmb1075. PMID 16547514. S2CID 868532.
  19. ^ Godfrey AC, Kupsco JM, Burch BD, Zimmerman RM, Dominski Z, Marzluff WF, Duronio RJ (2006). "U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis". RNA. 12 (3): 396–409. doi:10.1261/rna.2270406. PMC 1383579. PMID 16495235.
  20. ^ Madocsai C, Lim SR, Geib T, Lam BJ, Hertel KJ (2005). "Correction of SMN2 Pre-mRNA splicing by antisense U7 small nuclear RNAs". Mol Ther. 12 (6): 1013–1022. doi:10.1016/j.ymthe.2005.08.022. PMID 16226920.
  21. ^ Azzouz TN, Pillai RS, Däpp C, Chari A, Meister G, Kambach C, Fischer U, Schümperli D (2005). "Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes". J Biol Chem. 280 (41): 34435–34440. doi:10.1074/jbc.M505077200. hdl:21.11116/0000-0007-E5F1-6. PMID 16087681.
  22. ^ Azzouz TN, Gruber A, Schümperli D (2005). "U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100 kDa zinc finger processing factor (ZFP100) and a ZFP100-independent function in histone RNA 3' end processing". Nucleic Acids Res. 33 (7): 2106–2117. doi:10.1093/nar/gki516. PMC 1075925. PMID 15824063.
  23. ^ Goyenvalle A, Vulin A, Fougerousse F, Leturcq F, Kaplan JC, Garcia L, Danos O (2004). "Rescue of dystrophic muscle through U7 snRNA-mediated exon skipping". Science. 306 (5702): 1796–1799. Bibcode:2004Sci...306.1796G. doi:10.1126/science.1104297. PMID 15528407. S2CID 9359783.
  24. ^ Schümperli D, Pillai RS (2004). "The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein" (PDF). Cell Mol Life Sci. 61 (19–20): 2560–2570. doi:10.1007/s00018-004-4190-0. PMID 15526162. S2CID 5780814.
  25. ^ Liu S, Asparuhova M, Brondani V, Ziekau I, Klimkait T, Schümperli D (2004). "Inhibition of HIV-1 multiplication by antisense U7 snRNAs and siRNAs targeting cyclophilin A". Nucleic Acids Res. 32 (12): 3752–3759. doi:10.1093/nar/gkh715. PMC 484190. PMID 15254276.
  26. ^ Azzouz TN, Schumperli D (2003). "Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster". RNA. 9 (12): 1532–1541. doi:10.1261/rna.5143303. PMC 1370506. PMID 14624008.
  27. ^ Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D (2003). "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing". Genes Dev. 17 (18): 2321–2333. doi:10.1101/gad.274403. PMC 196468. PMID 12975319.
  28. ^ Dominski Z, Yang XC, Purdy M, Marzluff WF (2003). "Cloning and characterization of the Drosophila U7 small nuclear RNA". Proc Natl Acad Sci U S A. 100 (16): 9422–9427. Bibcode:2003PNAS..100.9422D. doi:10.1073/pnas.1533509100. PMC 170934. PMID 12872004.
  29. ^ Brun C, Suter D, Pauli C, Dunant P, Lochmüller H, Burgunder JM, Schümperli D, Weis J (2003). "U7 snRNAs induce correction of mutated dystrophin pre-mRNA by exon skipping". Cell Mol Life Sci. 60 (3): 557–566. doi:10.1007/s000180300047. PMC 11138867. PMID 12737315. S2CID 42878523.
  30. ^ Dominski Z, Erkmann JA, Yang X, Sànchez R, Marzluff WF (2002). "A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing". Genes Dev. 16 (1): 58–71. doi:10.1101/gad.932302. PMC 155312. PMID 11782445.
  31. ^ Pillai RS, Will CL, Lührmann R, Schümperli D, Müller B (2001). "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein". EMBO J. 20 (19): 5470–5479. doi:10.1093/emboj/20.19.5470. PMC 125645. PMID 11574479.
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  36. ^ Dominski Z, Zheng LX, Sanchez R, Marzluff WF (1999). "Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA". Mol Cell Biol. 19 (5): 3561–70. doi:10.1128/mcb.19.5.3561. PMC 84148. PMID 10207079.
  37. ^ Müller B, Schümperli D (1997). "The U7 snRNP and the hairpin binding protein: Key players in histone mRNA metabolism". Semin Cell Dev Biol. 8 (6): 567–576. doi:10.1006/scdb.1997.0182. PMID 9642171.
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  41. ^ Turner PC, Whalen A, Schümperli D, Matera AG (1996). "The bona fide mouse U7 snRNA gene maps to a different chromosome than two U7 pseudogenes". Genomics. 31 (2): 250–252. doi:10.1006/geno.1996.0042. PMID 8824812.
  42. ^ Stefanovic B, Wittop Koning TH, Schümperli D (1995). "A synthetic histone pre-mRNA-U7 small nuclear RNA chimera undergoing cis cleavage in the cytoplasm of Xenopus oocytes". Nucleic Acids Res. 23 (16): 3152–3160. doi:10.1093/nar/23.16.3152. PMC 307172. PMID 7667091.
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Quelle: https://en.wikipedia.org/wiki/U7_small_nuclear_RNA