Twenty something or twentysomething may refer to:

• Twentysomething (term), a person in the age group of 20 to 29
• Twentysomething (album), by Jamie Cullum
• "Twenty-something", a 2016 single by Pet Shop Boys from the album Super
• Twenty Something (1994 film), a Hong Kong Film directed by Teddy Chan
• Twenty Something (2021 film), a 2D short film by Pixar Animation Studios
• Twentysomething (TV series), an Australian television series
• Twenty Something, a Pan Arab television show about local arts and culture, broadcast weekly on Dubai One starting January 17, 2010
• Twenty-Something, an alias used by electronic music producers Geert Huinink and Alco Lammers
• "20 Something", a song by Dala from the album Angels & Thieves